The real cost of trucking is broken down in the following infographic from the Truckers Report.

Fuel costs lead the charge against your profit averaging 39% of total operating costs.  All-in costs yield a $1.38 per mile operating expense, about $180,000 per year per truck.  With driver salaries accounting for 26% of total operating costs the two combined form a 1-2 punch on your wallet.

Cost of Trucking Per Mile

Trucking Infographics by TruckersReport